AvaSpec in MultiSpec Analyzer of Chemotherapy Bags
AvaSpec in MultiSpec Analyzer of ChemotherapyBags
Over the past few years Microdom has focussed its R&D activity on spectroscopic analysers designed for the control of chemotherapy infusion bags prior to dispensation to cancer patients. The bags of cytotoxic solutions have to be compounded at “point of care” (hospital or cancer institute pharmacy) for two main reasons:
- The formulation is customized for each patient: type of molecule, molecule concentration, type of vector (glucose, NaCl).
- The stability of the active molecules once in solution is reduced.
3 main parameters are essential to qualify the produced cytotoxic bags:
- Molecule identification
- Solvent identification
- Molecule concentration.
In order to meet these requirements Microdom has developed an innovative concept based on the coupling of 2 spectrometers (patented design): a UV/Vis spectrometer from Avantes (200-700 nm) and a FTIR spectrometer. An auto-sampler from Gilson is used to inject the samples into the measure cells of the analyser. The UV/Vis spectrometer is fundamental for the quantification step since most molecules absorb at the low end of the UV range. The FTIR spectrometer on the other hand is essential for the identification step and the quantification of highly absorbent solutions (the dilution step is thus avoided). The system has been successfully marketed in France for the past 2 years. The international deployment is now starting.
