There are numerous biomedical applications for spectroscopy including everything from blood testing to cancer research. In fact, spectroscopy is at the forefront of many medical advancements currently in development.
In the quest to develop non-invasive monitoring and testing for diabetes, researchers are investigating several different avenues, many of which employ spectroscopic methods, often in combination with other investigative techniques. One of these methods under investigation is NIR spectroscopy. Near-infrared radiation and even the lower visible-range red light between 650 and 1100 nm fall into what doctors and medical researchers call the diagnostic or therapeutic window. This wavelength range allows light to penetrate the furthest into living tissue without causing any damage to the subject, there is little absorption from water or hemoglobin to interfere with the signal in this range, and less scattering than in the UV. Combining NIR spectroscopy with the finger-printing like capabilities of Raman spectroscopy also shows tremendous promise, but developing reference calibrations is more difficult.
One diagnostic method for non-invasive diabetes testing being developed would use fingernail clippings as the test sample. Aside from the speed of results and simple sample preparation required, the sample would also not require refrigeration. These considerations are incredibly important in the developing world.
The latest addition to the Avantes NIRLine of spectrometers, the AvaSpec-NIR512-1.7-EVO, offers the ideal response for even the most demanding near-infrared application.
The semiconductor industry relies heavily on spectroscopy during the manufacturing process. Used for end-point detection, thin film and coating metrology, laser etching, and more; it could be said that spectroscopy is at the heart of the modern computer age.
Plasma diagnostics and end point detection require rapid data acquisition and high resolution. These instruments frequently require intensity calibration with a NIST traceable calibration source. The ideal instrument solution would be the Avantes AvaSpec-ULS2048CL-EVO ultra-low light spectrometer employs the state of the art EVO AS7010 electronics board alongside the latest series CMOS detector array for fast acquisition and data transfer.
Ultra-violet and Visible light absorbance spectroscopy is the cornerstone of spectroscopy measurements. Closely related to transmission and reflection spectroscopy, applications for absorbance are found in dozens of fields and industries and encompass related specialized applications. UV/Vis Absorbance can provide qualitative and quantitative on relatively small samples in any physical state at relatively low cost, and when paired with fiber optic sampling accessories, even from a distance.
Avantes compact modular instruments covering 200-1100 nm offer amazing versatility and scalability in system design. The entire Avantes product line is designed for perfect compatibility, allowing the user to add additional functionality, such as pairing multiple instruments or adding and NIR instrument for broad range coverage.
Optical Emission Spectroscopy is a plasma measurement technique often used in semiconductor and electronics manufacturing applications to measure plasma etching of photoresist light sensitive material used in coatings. OES techniques are also used in energy research and even in the biomedical industry. Optical Emission spectroscopy relies on analyzing the unique spectra emission by each element on the periodic table, often in minute quantities. The AvaSpec-ULS2048CL-EVO is a favorite for many OES applications where the 0.1 nm (FWHM) resolution is needed to detect many atomic emission lines.
At the Institut für Raumfahrtsysteme (Space Systems) at the University of Stuttgart, Inductively-Coupled Plasma (ICP) Plasma facility, researchers use the Plasma Wind Tunnel (PWK3) to simulate atmospheric reentry for Thermal Protection Systems (TPS) testing and to perform experiments with radiation in pure gas environments. In a system like this, Avantes spectrometers are used to calibrate plasma conditions at the boundary layer between sample and free stream plasma. These conditions would be impossible to monitor live in-situ without the use of fiber optics for remote measurements.
While photonics technologies have powered many recent innovations, and are at the forefront of many other leading technological advances, optical components require testing, validation, and calibration. Manufacturers of optical components employ spectrometers to perform functions such as laser characterization, optical component profiling, and LED reliability testing.
Lasers are an essential component of many spectrometry and photonics applications, but such applications often require incident laser emissions within a relatively narrow wavelength or power output range. In the manufacturing of optical components such as filters, lenses, and coatings, it is not uncommon that suppliers must validate the optical properties. Additionally, the makers of lighting sources such as LEDs will use spectrometers for quality and reliability testing. Avantes has numerous spectrometer solutions for photonics applications, with some instruments capable of achieving resolution down to 0.05 nm in the ultraviolet, 0.07 nm in the visible, and 0.15 nm in the SWIR.
In climate and environmental research, spectroscopy plays a significant role because of its versatility. Spectroscopy’s capability for measuring any physical state: gas, liquid, solid, or plasma and the non-destructive nature of the technique allow researchers in hundreds of fields and disciplines use spectroscopy to advance their work.
NASA has developed the Pandora system primarily as a ground-based trace gas monitoring system, however the Pandora system has also been deployed in aerial and naval climate monitoring campaigns as well. The Pandora system, based on the AvaSpec-ULS2048x64 back-thinned CCD spectrometer, the Pandora can provide near continuous spatial monitoring of ground-level Ozone (O3) and Nitrogen Dioxide (NO2) a precursor to Ozone or measure airborne particulate matter such as a study monitoring the amount of airborne sand carried from Northern Africa across the Mediterranean to airspace over southern Italy and Greece.
Spectroscopy is an excellent technique choice for live near-continuous pollution and air/water quality monitoring and Avantes instruments are widely trusted in this field.
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